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Ketamine has been used medically as a topical pain cream ingredient for its ability to block N-methyl-D-aspartate (NMDA) receptors, which has been shown to help in decreasing pain perception, and decreasing sensation of pain.

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Researchers began to examine the use of ketamine as a treatment for major depressive disorder (MDD) in the 2000s.  Since then, ketamine has been shown to also help with drug treatment resistant depression, as well as depression combined with anxiety. 

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Ketamine powder for sale, ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, and it blocks HCN1 receptors. However, at higher doses it may also bind to the opioid mu and sigma receptors.
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Glutamate is involved with learning, memory, emotion, and pain recognition. It can exhibit sympathomimetic activity which can lead to rapid heart rate and elevated blood pressure.
It is related to phencyclidine (PCP) but has less than 10% of the potency of pure PCP.  And so, this agent is a lipid soluble compound. And has an initial rapid distribution and large volume of distribution, with a half-life of 10 to 15 minutes.

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If you give a positive sample and you are taking your medicine as directed by the prescriber or a healthcare professional and you’re driving is NOT impaired, then you are NOT breaking the law and you can raise a “medical defense”.
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The effects of taking ketamine with other drugs– including over-the-counter or prescribed medications – can be unpredictable and dangerous, and could cause:

  • Ketamine + alcohol or opiates: lack of awareness of effects of the depressant drugs, which may lead to taking too much and vomiting, slowed breathing, coma and death.
  • Ketamine + amphetamines, ecstasy and cocaine: enormous strain on the body, which can lead to fast heart rate.


Giving up ketamine after using it for a long time is challenging because the body has to get used to functioning without it. Withdrawal symptoms usually last for 4-6 days. These symptoms can include:

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