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Ketamine has been used medically as a topical pain cream ingredient for its ability to block N-methyl-D-aspartate (NMDA) receptors, which has been shown to help in decreasing pain perception, and decreasing sensation of pain.

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Researchers began to examine the use of ketamine as a treatment for major depressive disorder (MDD) in the 2000s.  Since then, ketamine has been shown to also help with drug treatment resistant depression, as well as depression combined with anxiety. 

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It is related to phencyclidine (PCP) but has less than 10% of the potency of pure PCP.  And so, this agent is a lipid soluble compound. And has an initial rapid distribution and large volume of distribution, with a half-life of 10 to 15 minutes.

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The effects of taking ketamine with other drugs– including over-the-counter or prescribed medications – can be unpredictable and dangerous, and could cause:

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